The alterations in enzymatic and biochemical activities were investigated in the brain of Swiss albino mice, with (experimental) or without (control) fruit extract before exposure to 5 Gy gamma radiation. The value of serum acid phosphatase activity were significantly higher in the irradiated group throughout the experiments compared to normal. However, this activity in Emblica officinalis pretreated irradiated animals showed a significant decline over untreated irradiated animals at all the autopsy intervals and attained the normal value by day 20th of treatment conversely, a marked decrease in serum alkaline phosphatase activity was noted in both the irradiated groups, but in the Emblica officinalis pretreated group an elevation in protein and cholesterol levels was observed. Furthermore, Emblica officinalis inhibited lipid peroxidation and increased glutathione (GSH) level in brain.

doi; 10.5214/ans.0972.7531.2006.130302