Age related macular degeneration (AMD) is the most common cause of visual impairment and is characterized by drusen formation, geographic atrophy and gradual loss of vision. It is a frightening disease that destroys the macula, the central part of retina, severely regimenting a person's normal sight. The utility of mouse models with features of AMD along with its recently reported association with complement factor H-gene, and TLR 4 genes strongly suggest the importance of inflammatory mediators and complement in the pathogenesis of this disease. Current treatment modalities include photodynamic therapy and photocoagulation, however, their efficacy is limited. The animal models that faithfully replicate the features of human AMD are useful platforms in validating new therapies. This not only provides new insights for preventative and restorative approaches in AMD in future but also advances our understanding of cardiovascular and neurodegenerative disorders.

doi : 10.5214/ans.0972.7531.2009.160208

Competing interests: None.     Source of Funding: None

Received Date: 01 April 2009     Revised Date: 25 April 2009     Accepted Date: 02 May 2009