Annals of Neurosciences, Vol 21, No 1 (2014)

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Sonic Hedgehog Signalling Pathway: A Complex Network

Nusrat J Mobassarah, Zia Choudhry, Azadeh A Rikani, Adnan M Choudhry, Sadaf Tariq, Fozia Zakaria, Muhammad W Asghar, Muhammad K Sarfraz, Kamran Haider, Afia A Shafiq



Sonic Hedgehog (Shh) signalling cascade is one of the intricate signal transduction mechanisms that govern the precisely regulated developmental processes of multicellular organisms. Along with establishing the patterns of cellular differentiation to direct complex organ formation, it also has an important role in post-embryonic tissue regeneration and repair processes. Especially, Shh signalling is implicated in the induction of multifarious neuronal populations in central nervous system. There are compelling evidences of the involvement of Shh protein in the signalling network that regulates various morphogenetic processes such as the exquisite neural tube pattern formation. In the morphogenetic field, the activation of Shh signalling processes is intricately linked to the molecular level alterations in the structure of Shh protein that leads to its transformed biophysical and biochemical reactivity. This brief article gives an overview of such complex cascade of events in Shh signalling and its transduction pathways.

Competing interests - None; Source of Funding - None; Received Date : 5 November, 2013; Revised Date : 11 January, 2014; Accepted Date : 25 February, 2014

doi : 10.5214/ans.0972.7531.210109



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